Nerve growth factor regulates the action potential duration of mature sensory neurons.
نویسندگان
چکیده
منابع مشابه
Influence of nerve growth factor on neurofilament gene expression in mature primary sensory neurons.
To analyze the possible influence of nerve growth factor (NGF) on neurofilament synthesis in primary sensory neurons, adjacent cryostat sections of lumbar dorsal root ganglia (DRG) from adult rats were processed for either NGF-receptor radioautography or in situ hybridization with a neurofilament cDNA probe. Labeling by both procedures was quantified with computer assistance for approximately 3...
متن کاملNerve growth factor (NGF) differentially regulates the chemosensitivity of adult rat cultured sensory neurons.
We have studied the effects of NGF on the chemosensitivity of adult rat DRG neurons over a 1-2 week period in vitro, using voltage-clamp and radioactive ion flux methods. A sustained proton evoked current was reversibly lost in NGF-free medium after 1 week. Proton-evoked efflux of radioactive 86Rb+ ions was also depressed in NGF deprived cultures, although depolarization with 40 mM potassium st...
متن کاملCarbon nanotubes prolong the regulatory action of nerve growth factor on the endocannabinoid signaling
Introduction: Carbon nanotubes (CNTs) have shown enormous potential in neuroscience. Nerve growth factor (NGF)-CNTs complex promotes the neuronal growth, however, the underlying mechanism(s) have remained elusive. Based on the interplay between NGF and the endocannabinoid system, involvement of the neuroprotective endocannabinoid, 2-arachidonoyl glycerol (2-AG), was investigated in the mechanis...
متن کاملEstrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons.
We have previously shown that neurons in the basal forebrain colocalize the neurotrophin receptor p75NGFR and estrogen receptors. The present study was designed to examine (1) if neural neurotrophin targets respond to estrogen as a general phenotypic feature and (2) if NGF receptor mRNAs are regulated by estrogen, using a prototypical target of NGF, the dorsal root ganglion (DRG) (sensory) neur...
متن کاملNerve growth factor receptors on normal and injured sensory neurons.
The density and binding properties of receptors for nerve growth factor (NGF) in normal and injured sensory neurons have been analyzed by quantitative radioautography following incubation of tissue sections with radioiodinated NGF. The technique is designed to study binding sites that are half-maximally saturated by picomolar concentrations of NGF: Additional sites of lower affinity have not be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1987
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.84.1.289